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ALZHEIMER DISEASE

In search of an anti-inflammatory drug for Alzheimer disease

Nature Reviews Neurology volume 16, pages 131–132 (2020)Cite this article

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Evidence suggests that chronic neuroinflammation has an important role in the pathogenesis of Alzheimer disease. However, in a new clinical trial, the tetracycline antibiotic minocycline, which has anti-inflammatory properties, failed to delay disease progression in individuals with mild Alzheimer disease.

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Fig. 1: Change in sMMSE score from baseline to month 24.

References

  1. Mrak, R. E. & Griffin, W. S. Glia and their cytokines in progression of neurodegeneration. Neurobiol. Aging 26, 349–354 (2005).

    Article  CAS  Google Scholar 

  2. Lambert, J. C. et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease. Nat. Genet. 41, 1094–1099 (2009).

    Article  CAS  Google Scholar 

  3. Jonsson, T. et al. Variant of TREM2 associated with the risk of Alzheimer’s disease. N. Engl. J. Med. 368, 107–116 (2013).

    Article  CAS  Google Scholar 

  4. Wilkins, H. M. et al. Mitochondrial lysates induce inflammation and Alzheimer’s disease-relevant changes in microglial and neuronal cells. J. Alzheimers Dis. 45, 305–318 (2015).

    Article  CAS  Google Scholar 

  5. Howard, R. et al. Minocycline at 2 different dosages versus placebo for patients with mild Alzheimer disease: a randomized clinical trial. JAMA Neurol. https://doi.org/10.1001/jamaneurol.2019.3762 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Elewa, H. F., Hilali, H., Hess, D. C., Machado, L. S. & Fagan, S. C. Minocycline for short-term neuroprotection. Pharmacotherapy 26, 515–521 (2006).

    Article  CAS  Google Scholar 

  7. Garcez, M. L. et al. Minocycline reduces inflammatory parameters in the brain structures and serum and reverses memory impairment caused by the administration of amyloid beta (1–42) in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 77, 23–31 (2017).

    Article  CAS  Google Scholar 

  8. Zhou, M., Kaelber, D., Xu, R. & Gurney, M. Tumor necrosis factor (TNF) blocking agents reduce risk for Alzheimer’s disease in patients with rheumatoid arthritis and psoriasis. Preprint at medRXiv https://www.medrxiv.org/content/10.1101/19007666v1 (2019).

  9. Venigalla, M., Sonego, S., Gyengesi, E., Sharman, M. J. & Münch, G. Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer’s disease. Neurochem. Int. 95, 63–74 (2016).

    Article  CAS  Google Scholar 

  10. Dupont, A. C. et al. Translocator protein-18 kDa (TSPO) positron emission tomography (PET) imaging and its clinical impact in neurodegenerative diseases. Int. J. Mol. Sci. 18, 785 (2017).

    Article  Google Scholar 

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Authors and Affiliations

  1. Pharmacology Unit, School of Medicine, Western Sydney University, Campbelltown, Australia

    Erika Gyengesi & Gerald Münch

  2. NICM Health Research Institute, Western Sydney University, Westmead, Australia

    Gerald Münch

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  1. Erika Gyengesi
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  2. Gerald Münch
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Correspondence to Gerald Münch.

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The authors declare no competing interests.

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Gyengesi, E., Münch, G. In search of an anti-inflammatory drug for Alzheimer disease. Nat Rev Neurol 16, 131–132 (2020). https://doi.org/10.1038/s41582-019-0307-9

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