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TRAUMATIC BRAIN INJURY

Meningeal lymphatic flow slows after mild traumatic brain injury

Nature Reviews Neurology volume 16, page 600 (2020)Cite this article

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Impaired drainage of fluid via the meningeal lymphatics occurs after mild traumatic brain injury (TBI) and could worsen cognitive symptoms, according to new research published in Nature Communications. The work, which was performed in mice, suggests that enhancing meningeal lymphatic drainage could help treat post-concussive symptoms.

Following TBI, the immune system removes toxic material, such as necrotic cells and cellular debris, from the brain. Evidence suggests that meningeal lymphatics are involved in the drainage of this material from the brain to the deep cervical lymph nodes (dCLN), but the role of this waste-removal system in TBI is not yet clear. The new study, which was led by John Lukens, aimed to address this gap in our knowledge.

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References

Original article

  • Bolte, A. C. et al. Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis. Nat. Commun. 11, 4524 (2020)

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Related article

  • Wardlaw, J. M. et al. Perivascular spaces in the brain: anatomy, physiology and pathology. Nat. Rev. Neurol. 16, 137–153 (2020)

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Sarah Lemprière

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  1. Sarah Lemprière
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Correspondence to Sarah Lemprière.

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Lemprière, S. Meningeal lymphatic flow slows after mild traumatic brain injury. Nat Rev Neurol 16, 600 (2020). https://doi.org/10.1038/s41582-020-00420-5

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