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Alzheimer disease

ApoE attracts microglia to amyloid-β plaques

Nature Reviews Neurology volume 19, page 639 (2023)Cite this article

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The cell adhesion molecule VCAM1 directs microglia towards ApoE-associated amyloid-β (Aβ) plaques, leading to Aβ clearance, according to new research published in Nature Aging. The results of the study highlight this signalling pathway as a potential therapeutic target for Alzheimer disease (AD).

Using single-cell RNA sequencing of microglia from APP/PS1 mice (a model of AD), the researchers profiled transcriptional changes during the transition of microglia in response to IL-33. The results demonstrated a sequential transition from a homeostatic state to chemotactic then phagocytic states.

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Lisa Kiani

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  1. Lisa Kiani
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Correspondence to Lisa Kiani.

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Kiani, L. ApoE attracts microglia to amyloid-β plaques. Nat Rev Neurol 19, 639 (2023). https://doi.org/10.1038/s41582-023-00885-0

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