Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • In Brief
  • Published:

Alzheimer disease

Regional vulnerability to Aβ and tau pathology

Nature Reviews Neurology volume 20, page 133 (2024)Cite this article

Subjects

The vulnerability of specific brain regions to Alzheimer disease (AD) pathology is associated with expression profiles of AD susceptibility genes, according to new research. To characterize regional vulnerability, Yu et al. compared tau and amyloid-β (Aβ) PET imaging data from people with cognitive impairment, including AD and mild cognitive impairment, and cognitively unimpaired individuals. Transcriptomic analysis revealed spatial associations between the gene-expression profiles of 45 AD susceptibility genes and regional vulnerability to tau or Aβ deposition. APOE and MAPT were among the genes most strongly associated with tau pathology, whereas TMEM106B (which encodes a lysosomal membrane protein) and CNTNAP2 (which is involved in neuroglia interactions) showed the strongest association with Aβ pathology.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

Original article

  • Yu, M. et al. Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer’s disease. Cell Rep. 43, 113691 (2024)

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Lisa Kiani

Authors
  1. Lisa Kiani
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Lisa Kiani.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kiani, L. Regional vulnerability to Aβ and tau pathology. Nat Rev Neurol 20, 133 (2024). https://doi.org/10.1038/s41582-024-00934-2

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41582-024-00934-2

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing