Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • In Brief
  • Published:

Alzheimer disease

Immune rejuvenation — a potential AD therapy

Nature Reviews Neurology volume 20, page 456 (2024)Cite this article

Subjects

Access through your institution
Buy or subscribe

A new study shows that transplantation of bone marrow from young mice can reduce amyloid pathology and ameliorate cognitive deficits in a mouse model of Alzheimer disease (AD). Aged (9-month-old) APP/PS1 mice received bone marrow from 2-month-old or 9-month-old APP/PS1 mice. The young bone marrow transplants led to reductions in cerebral amyloid plaque burden (attributed to increased amyloid-β clearance from the brain by blood monocytes) and improved performance on behavioural tests. The findings warrant further exploration of immune system rejuvenation to treat AD.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

Original article

  • Sun, P.-Y. et al. Rejuvenation of peripheral immune cells attenuates Alzheimer’s disease-like pathologies and behavioral deficits in a mouse model. Sci. Adv. 10, eadl1123 (2024)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Heather Wood

Authors
  1. Heather Wood
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Heather Wood.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wood, H. Immune rejuvenation — a potential AD therapy. Nat Rev Neurol 20, 456 (2024). https://doi.org/10.1038/s41582-024-00996-2

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41582-024-00996-2

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing