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Alzheimer disease

Microglia underlie amyloid-β clearance in immunized people with Alzheimer disease

Nature Reviews Neurology volume 21, page 233 (2025)Cite this article

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A study published in Nature Medicine has found that microglia are responsible for amyloid-β (Aβ) clearance in people with Alzheimer disease (AD) treated with Aβ immunotherapies.

Transcriptomic analysis of frontal cortex sections revealed brain region-specific differential expression of genes involved in microglial function in people with AD treated with active Aβ immunotherapy AN1792, as compared with untreated individuals. Established AD risk genes that are involved in the microglial response, including TREM2 and APOE, were among the upregulated genes in treated individuals, and their expression correlated positively with Aβ removal. Similar results were observed in one individual treated with the approved monoclonal antibody lecanamab.

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Lisa Kiani

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  1. Lisa Kiani
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Correspondence to Lisa Kiani.

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Kiani, L. Microglia underlie amyloid-β clearance in immunized people with Alzheimer disease. Nat Rev Neurol 21, 233 (2025). https://doi.org/10.1038/s41582-025-01084-9

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  • DOI: https://doi.org/10.1038/s41582-025-01084-9

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