The modulating influence of biological sex on clinical variability, disease trajectories and treatment response represents a nascent topic in frontotemporal dementia (FTD) research. Recent empirical studies leveraging large-scale consortium data illuminate how biological sex impinges on — and potentially interacts with — variations in clinical symptomatology, pathophysiology and disease trajectory in FTD.
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Acknowledgements
M.I. is supported by a National Health and Medical Research Council of Australia Investigator Grant — Leadership L1 (GNT2025228) and a Medical Research Future Fund Dementia Ageing and Aged Care Mission Grant (GNT2024329) from the Australian Government Department of Health and Aged Care. The funding sources had no role in the conceptualization or writing of this article.
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Irish, M. Sex differences in frontotemporal dementia. Nat Rev Neurol 21, 471–472 (2025). https://doi.org/10.1038/s41582-025-01124-4
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DOI: https://doi.org/10.1038/s41582-025-01124-4
