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Preventing immune-complex-mediated disease

Nature Reviews Rheumatology volume 15, page 4 (2019)Cite this article

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Immune-complex deposition and Fcγ receptor (FcγR)-mediated activation of inflammatory responses by such immune complexes is a central pathogenic process in a variety of autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and vasculitis. A new study reports the development of a humanized anti-FcγRIIA antibody (VIB9600) that might function as a broad-spectrum therapy for these and other diseases.

The researchers now show that VIB9600 can inhibit immune-complex responses in a variety of contexts, but importantly without also targeting the highly homologous (but inhibitory) FcγRIIB and without activating antibody-dependent or complement-dependent cytotoxicity.

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  1. Nature Reviews Rheumatology http://www.nature.com/nrrheum/

    Nicholas J. Bernard

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  1. Nicholas J. Bernard
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Correspondence to Nicholas J. Bernard.

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Bernard, N.J. Preventing immune-complex-mediated disease. Nat Rev Rheumatol 15, 4 (2019). https://doi.org/10.1038/s41584-018-0137-y

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