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Wnt signalling in the gut microbiota–bone axis

Nature Reviews Rheumatology volume 15, page 4 (2019)Cite this article

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The probiotic strain Lactobacillus rhamnosus GG (LGG) can promote bone formation and increase bone density in mice. New findings published in Immunity provide insights into this gut microbiota–bone pathway, which might have therapeutic implications for diseases such as osteoporosis.

The researchers found that, as expected, dietary supplementation with LGG resulted in increased bone formation and bone mass in young mice. In the gut, LGG indirectly stimulated the production of butyrate by expanding strains of butyrate-producing bacteria.

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  1. Nature Reviews Rheumatology http://www.nature.com/nrrheum/

    Jessica McHugh

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  1. Jessica McHugh
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Correspondence to Jessica McHugh.

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McHugh, J. Wnt signalling in the gut microbiota–bone axis. Nat Rev Rheumatol 15, 4 (2019). https://doi.org/10.1038/s41584-018-0139-9

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