Studies across multiple autoimmune diseases, including rheumatoid arthritis and coeliac disease, have identified a pathologically expanded PD1hiCXCR5−CD4+ T cell population that accumulates in inflamed tissues. Can this peripheral T helper cell population be harnessed as a predictive biomarker or targeted therapeutically in these diseases?
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Acknowledgements
The work of the author is supported by the Lupus Research Alliance, a Burroughs Wellcome Fund Career Award in Medical Sciences and the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (grant number K08 AR072791-01).
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D.A.R. declares he has received consulting fees from Janssen, Pfizer and Scipher Medicine, research grant support from Merck and is co-inventor of patent WO2017213695A1, submitted on T peripheral helper cells.
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Rao, D.A. The rise of peripheral T helper cells in autoimmune disease. Nat Rev Rheumatol 15, 453–454 (2019). https://doi.org/10.1038/s41584-019-0241-7
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DOI: https://doi.org/10.1038/s41584-019-0241-7
