Table 1 Main clinical features of ANCA-positive and ANCA-negative EGPA in three large cohorts
Clinical feature | Comarmond et al. (2013)6 | Sinico et al. (2005)11 | Healy et al. (2013)9 | ||||||
|---|---|---|---|---|---|---|---|---|---|
ANCA+ (n = 108) | ANCA− (n = 240) | P value | ANCA+ (n = 35) | ANCA− (n = 58) | P value | MPO-ANCA+ (n = 15) | ANCA− (n = 55) | P value | |
Asthma | 93% | 91% | ns | 97% | 95% | ns | 100% | 100% | ns |
Sinusitis | 52% | 38% | 0.02 | 77% | 78% | ns | 60% | 64% | ns |
Lung involvement (any kind) | 93% | 91% | ns | 34% | 60% | 0.02 | 40% | 76% | <0.01 |
Alveolar haemorrhage | 7% | 3% | ns | 20% | 0 | 0.001 | na | na | na |
Heart involvementa | 8%a | 19%a | 0.01a | 6% | 22% | 0.04 | 0 | 38% | <0.01 |
Gastrointestinal involvement | 22% | 23% | ns | 20% | 22% | ns | 0 | 14% | 0.03 |
Skin involvement (any kind) | 45% | 36% | ns | 60% | 48% | ns | 67% | 62% | ns |
Purpura | 29% | 20% | ns | 26% | 7% | 0.02 | 53% | 40% | ns |
Peripheral neuropathy (any kind) | 63% | 44% | <0.01 | 71% | 60% | ns | 73% | 42% | 0.02 |
Mononeuritis multiplex | 55% | 39% | <0.01 | 51% | 24% | 0.01 | na | na | na |
CNS involvement | 7% | 4% | ns | 17% | 12% | ns | 20% | 13% | ns |
Renal involvement | 27% | 16% | 0.02 | 51% | 12% | <0.001 | 33% | 16% | ns |
Vasculitis on biopsy | na | na | na | 76% | 32% | <0.001 | 81% | 61% | ns |
