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Clarity for the language of race, ethnicity and genetic ancestry in rheumatology

As the pace of genetic discovery has accelerated, so too has the need for clinicians and researchers to acknowledge and understand the impact of language in scientific publications. The use of inaccurate language contributes to systemic bias and eugenic ideologies that remain pervasive in biomedical science, including in rheumatology.

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References

  1. Olson, R. M. & Feldman, C. H. A critical look at race-based practices in rheumatology guidelines. Arthritis Care Res. 74, 1602–1607 (2022).

    Article  Google Scholar 

  2. Cho, M. K. et al. Words matter: the language of difference in human genetics. Genet. Med. 25, 100343 (2023).

    Article  CAS  PubMed  Google Scholar 

  3. Bentz, M., Saperstein, A., Fullerton, S. M., Shim, J. K. & Lee, S. S. Conflating race and ancestry: tracing decision points about population descriptors over the precision medicine research life course. HGG Adv. 5, 100243 (2024).

    PubMed  Google Scholar 

  4. Yusuf, A. A., Govender, M. A., Brandenburg, J. T. & Winkler, C. A. Kidney disease and APOL1. Hum. Mol. Genet. 30, R129–R137 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Bhopal, R. The beautiful skull and Blumenbach’s errors: the birth of the scientific concept of race. Br. Med. J. 335, 1308–1309 (2007).

    Article  Google Scholar 

  6. Carlson, J., Henn, B. M., Al-Hindi, D. R. & Ramachandran, S. Counter the weaponization of genetics research by extremists. Nature 610, 444–447 (2022).

    Article  CAS  PubMed  Google Scholar 

  7. Alarcon, G. S. et al. Ethnic disparities in health and disease: the need to account for ancestral admixture when estimating the genetic contribution to both (LUMINA XXVI). Lupus 14, 867–868 (2005).

    CAS  PubMed  Google Scholar 

  8. Johnson, R. et al. Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative. Genome Med. 14, 104 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Lewis, A. C. F. et al. Getting genetic ancestry right for science and society. Science 376, 250–252 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Sheikh, S. Z. et al. EMBRACE: One small story in lupus-one giant challenge in clinical trials. ACR Open Rheumatol. 4, 747–752 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The work of P.S.R. is supported by the US National Institute on Minority Health and Health Disparities of the US National Institutes of Health (grant number R01 MD015395), and by the US National Institute of Arthritis and Musculoskeletal and Skin Diseases (grant number P30 AR072582). The work of S.S.L. is supported by the National Center for Chronic Disease Prevention and Health Promotion (grant number U01 DP006698).

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Correspondence to Paula S. Ramos.

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Ramos, P.S., Lim, S.S. Clarity for the language of race, ethnicity and genetic ancestry in rheumatology. Nat Rev Rheumatol 20, 453–454 (2024). https://doi.org/10.1038/s41584-024-01129-1

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