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Immunometabolism

Itaconate targets fibroblast-like synoviocytes in RA

Nature Reviews Rheumatology volume 20, page 456 (2024)Cite this article

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Itaconate, an endogenous metabolite of the tricarboxylic acid (TCA) cycle, is known to have immunomodulatory and antimicrobial properties, but its role in the pathogenesis of rheumatoid arthritis (RA) is unclear. New research has explored whether itaconate could have therapeutic effects in RA by affecting the aggressive phenotype of fibroblast-like synoviocytes (FLSs).

RA-FLSs are known to have a dysregulated metabolic profile, and inhibition of glycolysis can decrease the proliferation and migration of RA-FLSs and ameliorates experimental arthritis. Having shown previously that itaconate metabolically regulates T cell differentiation and attenuates the severity of a model of T cell-driven autoimmune disease, Tada et al. sought to determine the effects of itaconate on RA-FLSs and its potential as a treatment for RA.

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References

Original article

  • Tada, M. et al. Itaconate reduces proliferation and migration of fibroblast-like synoviocytes and ameliorates arthritis models. Clin. Immunol. 264, 110255 (2024)

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Related article

  • Fearon, U. et al. Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications. Nat. Rev. Rheumatol. 18, 398–414 (2022)

    Article  CAS  PubMed  Google Scholar 

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  1. Nature Reviews Rheumatology http://www.nature.com/nrrheum/

    Sarah Onuora

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  1. Sarah Onuora
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Correspondence to Sarah Onuora.

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Onuora, S. Itaconate targets fibroblast-like synoviocytes in RA. Nat Rev Rheumatol 20, 456 (2024). https://doi.org/10.1038/s41584-024-01142-4

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  • DOI: https://doi.org/10.1038/s41584-024-01142-4

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