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Spondyloarthritis

Defining axial involvement in juvenile SpA

New classification criteria for axial disease in juvenile spondyloarthritis aim to enhance the identification and study of this condition in affected youth, offering a tool for future non-interventional studies and interventional trials. Better understanding of the efficacy of various interventions in the axial domain could help tailor treatment strategies.

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References

  1. Weiss, P. F. et al. Classification criteria for axial disease in youth with juvenile spondyloarthritis. Arthritis Rheumatol. https://doi.org/10.1002/art.42959 (2024).

    Article  PubMed  Google Scholar 

  2. Flato, B., Aasland, A., Vinje, O. & Forre, O. Outcome and predictive factors in juvenile rheumatoid arthritis and juvenile spondyloarthropathy. J. Rheumatol. 25, 366–375 (1998).

    CAS  PubMed  Google Scholar 

  3. Weiss, P. F. et al. Enthesitis-related arthritis is associated with higher pain intensity and poorer health status in comparison with other categories of juvenile idiopathic arthritis: the Childhood Arthritis and Rheumatology Research Alliance Registry. J. Rheumatol. 39, 2341–2351 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Selvaag, A. M. et al. Early disease course and predictors of disability in juvenile rheumatoid arthritis and juvenile spondyloarthropathy: a 3 year prospective study. J. Rheumatol. 32, 1122–1130 (2005).

    PubMed  Google Scholar 

  5. Deodhar, A. et al. Three multicenter, randomized, double-blind, placebo-controlled studies evaluating the efficacy and safety of ustekinumab in axial spondyloarthritis. Arthritis Rheumatol. 71, 258–270 (2019).

    Article  CAS  PubMed  Google Scholar 

  6. Baeten, D. et al. Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis: results of a randomised, double-blind, placebo-controlled, proof-of-concept, dose-finding phase 2 study. Ann. Rheum. Dis. 77, 1295–1302 (2018).

    Article  CAS  PubMed  Google Scholar 

  7. Hueber, W. et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn’s disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 61, 1693–1700 (2012).

    Article  CAS  PubMed  Google Scholar 

  8. Poddubnyy, D. et al. Axial Involvement in Psoriatic Arthritis cohort (AXIS): the protocol of a joint project of the Assessment of SpondyloArthritis international Society (ASAS) and the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). Ther. Adv. Musculoskelet. Dis. 13, 1759720X211057975 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Weiss, P. F. et al. Data-driven magnetic resonance imaging definitions for active and structural sacroiliac joint lesions in juvenile spondyloarthritis typical of axial disease: a cross-sectional international study. Arthritis Care Res. 75, 1220–1227 (2023).

    Article  CAS  Google Scholar 

  10. Weiss, P. F. et al. Radiographs in screening for sacroiliitis in children: what is the value? Arthritis Res. Ther. 20, 141 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Denis Poddubnyy.

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Competing interests

D.P. has received research support from AbbVie, Eli Lilly, MSD, Novartis, Pfizer, consulting fees from AbbVie, Bristol-Myers Squibb, Eli Lilly, Janssen, Moonlake, Novartis, Pfizer and UCB, and speaker fees from AbbVie, Canon, DKSH, Eli Lilly, Janssen, MSD, Medscape, Novartis, Peervoice, Pfizer and UCB, and is a member of the Assessment of SpondyloArthritis International Society executive committee and of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis steering committee.

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Poddubnyy, D. Defining axial involvement in juvenile SpA. Nat Rev Rheumatol 21, 3–4 (2025). https://doi.org/10.1038/s41584-024-01170-0

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