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Vasculitis

Combination therapy for Behçet uveitis

Nature Reviews Rheumatology volume 20, page 667 (2024)Cite this article

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Behçet uveitis can be treated with a combination of immunomodulatory drugs and glucocorticoids. However, the optimal immunomodulator for this combination therapy remains unclear. A randomized, open-label, head-to-head trial has now compared the efficacy and safety of ciclosporin, interferon alfa-2a and adalimumab in combination with ongoing glucocorticoid treatment for the prevention of uveitis relapse in patients with Behçet syndrome.

The single-centre study enrolled 270 individuals with severe Behçet syndrome and uveitis who were being treated with glucocorticoids and were naive to anti-TNF therapy. The annualized rate of uveitis relapse was 1.84 (95% CI 1.40–2.44) with ciclosporin plus glucocorticoids, 1.44 (1.10–1.89) with interferon alfa-2a plus glucocorticoids and 0.95 (0.64–1.40) with adalimumab plus glucocorticoids.

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  1. Nature Reviews Rheumatology http://www.nature.com/nrrheum/

    Holly Webster

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  1. Holly Webster
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Correspondence to Holly Webster.

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Webster, H. Combination therapy for Behçet uveitis. Nat Rev Rheumatol 20, 667 (2024). https://doi.org/10.1038/s41584-024-01173-x

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  • DOI: https://doi.org/10.1038/s41584-024-01173-x

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