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Crystal arthritis

Current challenges in understanding the epidemiology of calcium pyrophosphate crystal deposition

Nature Reviews Rheumatology volume 21, pages 312–313 (2025)Cite this article

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Calcium pyrophosphate deposition (CPPD) disease is secondary to the pathological accumulation of calcium pyrophosphate (CPP) crystals inside joints and involves acute or chronic inflammatory arthritis. Epidemiological research on CPPD has been slow despite the suspected high prevalence of this condition. Here we highlight key challenges in CPPD imaging, diagnosis and nomenclature that need to be addressed for epidemiological research to progress at a faster pace.

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Authors and Affiliations

  1. ULR 2694 – METRICS, CERIM, Public Health Department, Lille University, Lille University Hospital, Lille, France

    Charlotte Jauffret

  2. Department of Rheumatology, Saint-Philibert Hospital, Lille Catholic University, ETHICS Laboratory, Lille, France

    Charlotte Jauffret & Tristan Pascart

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  1. Charlotte Jauffret
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  2. Tristan Pascart
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Correspondence to Charlotte Jauffret.

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Jauffret, C., Pascart, T. Current challenges in understanding the epidemiology of calcium pyrophosphate crystal deposition. Nat Rev Rheumatol 21, 312–313 (2025). https://doi.org/10.1038/s41584-025-01256-3

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