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The apprehension of seronegative rheumatoid arthritis

Nature Reviews Rheumatology volume 21, pages 575–576 (2025)Cite this article

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Seronegative rheumatoid arthritis (RA) is often misunderstood and underrecognized, and this leads to delays in diagnosis and treatment. Emerging studies highlight distinct features and unmet needs of seronegative RA, calling for increased awareness of the challenges faced by patients and the need for tailored therapeutic approaches to improve outcomes.

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Fig. 1: The long journey through apprehension and uncertainty for patients with seronegative RA compared to the less complicated path for patients with seropositive RA.

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Authors and Affiliations

  1. Division of Rheumatology, Mayo Clinic, Rochester, MN, USA

    Iqra Javed & Cynthia S. Crowson

  2. Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA

    Cynthia S. Crowson

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  1. Iqra Javed
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  2. Cynthia S. Crowson
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Correspondence to Cynthia S. Crowson.

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The authors declare no competing interests.

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Javed, I., Crowson, C.S. The apprehension of seronegative rheumatoid arthritis. Nat Rev Rheumatol 21, 575–576 (2025). https://doi.org/10.1038/s41584-025-01289-8

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