Extended Data Fig. 7: Analysis of microglial enhancers.
From: Innate immune memory in the brain shapes neurological disease hallmarks
Microglial enhancers were analysed in 9-month-old wild-type and APP23 (APP) mice treated intraperitoneally with 1 × LPS or 4 × LPS at 3 months of age. a, Exemplary UCSC browser images of genomic region around the Hif1a gene (normalized to input and library dimension). b, Numbers of regions with differentially regulated H3K4me1 levels. c, Heatmaps of H3K4me1 regions (centred on H3K27ac peaks). d, Pairwise correlations between the two replicates of H3K4me1 read densities in differentially regulated regions. e–g, Analyses of H3K27ac levels analogous to b–d for H3K4me1. n = 2 replicates (8–10 mice per replicate); differential enhancers showed a cumulative Poisson P < 0.0001.
