Extended Data Fig. 9: Peripherally applied cytokines induce immune memory in the brain.
From: Innate immune memory in the brain shapes neurological disease hallmarks
a, Experimental design. b, Cytokine responses in the brain, four weeks after peripheral cytokine application (n = 17, 5, 5, 21, 8, 8, 15 mice from left to right). Note that TNF dose-dependently enhances (low dose) or decreases (high dose) certain cytokines. Similar to high dose TNF, certain cytokines are also reduced by peripheral application of IL-10 four weeks earlier. c, Cytokine responses in the periphery are unaffected (n = 8, 21, 9, 5,10 mice). Data are means ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001 for one-way ANOVA with Tukey correction.
