Extended Data Table 1 Region-specific changes in volume and surface area by loss of Aspm in ferrets

From: Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size

  1. a, Multiple brain regions are significantly decreased in volume; the highest reduction was found in the frontal cortex of adult Aspm−/− ferrets (n = 3 per genotype). Subcortical regions were relatively preserved. b, The outer cortical surface is the most reduced in the frontal cortex followed by the lateral cortex. The parietal/occipital cortex is also decreased but the difference was not significant. The medial cortex shows no discernible decrease. c, d, DTI shows that the orientation of white matter tracts or connectivity is fundamentally unchanged in Aspm knockout ferrets except in the frontal cortex, which shows a modest decrease in fractional anisotropy (d). The directional map (c) shows white matter orientation. Red, green and blue indicate the medial–lateral, superior–inferior, and anterior–posterior components, respectively. Statistical analysis was performed using a two-tailed t-test. Data are mean ± s.e.m. NS, not significant.
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