Extended Data Fig. 8: Comparison of Gαi C-terminal peptide binding modes. | Nature

Extended Data Fig. 8: Comparison of Gαi C-terminal peptide binding modes.

From: Structure of the µ-opioid receptor–Gi protein complex

Extended Data Fig. 8

a–c, Side (top) and cytoplasmic (bottom) views of the μOR (green) with the last 11 residues of Gαi (gold) alone (a), compared to the β2AR(orange) with the last 11 residues of Gαs (light purple) (PDB code 3SN6) (b), or compared to metarhodopsin II (pink) in complex with an 11-residue Gtransducin (Gt) C-terminal peptide (dark purple) (PDB code 3PQR) (c). The μOR–Gi complex aligns best with the metarhodopsin II–Gt complex in terms of both TM6 displacement and position of the α5 peptide.

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