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a–d, Cryo-EM density (displayed as mesh) surrounding residues involved in DAMGO binding (a), μOR–Gαi interaction around ICL2 (b), ICL3 (c), and cytoplasmic ends of the μOR transmembrane helices (d). These figures accompany the models shown in Figs. 1e, 4b, 5a and 5c, respectively.