Extended Data Fig. 3: Cryo-EM of the ADO–A1R–Gi2 complex.
From: Structure of the adenosine-bound human adenosine A1 receptor–Gi complex
a, Representative VPP cryo-EM micrograph (of 3,220 recordings) of the ADO–A1R–Gi2 complex. b, Reference-free 2D class averages of the complex in LMNG and CHS detergent micelles. c, Gold-standard Fourier shell correlation (FSC) curves, showing the overall nominal resolution at 3.6 Å. d, FSC curves for the final model versus the final map and the half maps for overfitting validation (see Methods).
