Retraction to: Nature https://doi.org/10.1038/nature16193, published online 16 December 2015; corrected 20 January 2016.
In follow-up experiments to this Article, we have been unable to replicate key aspects of the original results. Most importantly, an RNA-dependent physical association of RORγt and DDX5 cannot be reproduced and is not substantiated upon further analysis of the original data. The authors therefore wish to retract the Article. We deeply regret this error and apologize to our scientific colleagues. Dan R. Littman, Benjamin Thomas, Ryan A. Flynn, Samuel J. Gavzy, Lin Wu, Sangwon V. Kim, Jason A. Hall, Emily R. Miraldi, Charles P. Ng, Frank Rigo, Sarah Meadows, Nina R. Montoya, Natalia G. Herrera, Ana I. Domingos, Fraydoon Rastinejad, Richard M. Myers, Frances V. Fuller-Pace, Richard Bonneau, Howard Y. Chang and Oreste Acuto agree to the Retraction. Wendy Huang declined to sign the Retraction letter.
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Huang, W., Thomas, B., Flynn, R.A. et al. Retraction Note: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions. Nature 562, 150 (2018). https://doi.org/10.1038/s41586-018-0311-z
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DOI: https://doi.org/10.1038/s41586-018-0311-z
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Wendy Huang
Dear colleagues,
I would like to share with you the reason for my dissent to sign the above retraction statement.
Following the publication of “DDX5 and its associated lncRNA Rmrp modulate Th17 cell effector functions” in 2015, researchers in my lab have independently confirmed the essential role of DDX5 in cultured Th17 cells from our own mouse colony and confirmed its association with lncRNAs as reported. I also received communications from other researchers stating that they confirmed the interaction between DDX5 and a Th17 cell transcription factor RORgt by co-immunoprecipitation as well as mass spec studies.
When I first heard of the challenges noted above, I requested that the evidence supporting the irreproducibility claims be shared with myself and all authors. I also inquired on the specifics of how repeat experiments were performed, including the use of key reagents and protocols, and offered to help troubleshoot remotely. However, I did not receive any reply. My reanalysis of available raw data together with other independent scientists have not identified errors that warrant retraction as suggested by COPE guidelines. The journal editor suggested that I post my statement of dissent below in this forum. I welcome any discussion of concerns or questions you may have.
“In an analytical replication study, the original data of the published work were re-analyzed by myself and multiple independent scientists and found that they do support the published findings. To my knowledge, numerous direct replication studies by others in multiple laboratories have confirmed that DDX5 and its associated lncRNA Rmrp modulate Th17 cell effector functions, just as the published title stated, and specific mutations of Rmrp altered its interaction with proteins and localization on chromatin DNA. Lastly, the communicating author has not provided me with any evidence supporting the claim of non-reproducibility.”
Sincerely,
Wendy Huang