Extended Data Fig. 2: Serially collected sampling supports a long-lived HSPCs as the cell of origin for most ARCH-PD clones.
From: Prediction of acute myeloid leukaemia risk in healthy individuals
a, b, VAF trajectory of persistent clones carrying putative driver mutations in controls (a) and pre-AML cases (b). Age is indicated on the x axis. Top, VAF is shown on the y axis and each persistent mutation is shown in a different colour, with circles denoting individual serial samples and solid lines representing the growth trajectory between serial samples. Bottom, dashed lines indicate the time interval between the last sampling and the end of follow-up (controls) or AML diagnosis (cases). c, Clonal growth rates (α) are shown for 27 control clones corresponding to 54 time points and 13 pre-AML clones corresponding to 15 time points. Box plot centres, hinges and whiskers represent the median, first and third quartiles and 1.5 × interquartile range, respectively.
