Extended Data Fig. 3: Performance of the combined model in predicting progression to AML.
From: Prediction of acute myeloid leukaemia risk in healthy individuals
a, Receiver operating characteristic curve for prediction of AML development using model 1 (see Methods). The red dot indicates the point on the curve with the highest positive predictive value with sensitivity of 41.9% and specificity of 95.7%. b, c, Kaplan–Meier estimates of time to AML diagnosis for individuals predicted to develop AML (red) and not develop AML (blue) using model 1 (b; hazard ratio, 10.38; P = 4.2 × 10−10, Wald test) and model 2 (c; hazard ratio, 10.75; P = 1.75 × 10−8, Wald test), from the point of enrolment until the end of follow-up for patients enrolled in the EPIC study.
