Extended Data Fig. 5: Cryo-EM structure of NfMCU in complex with saposin.
From: Cryo-EM structure of a fungal mitochondrial calcium uniporter
a, Cryo-EM map of NfMCU in complex with saposin (shown alternating between purple and pink). The map is low-pass filtered to 5 Å to allow better visualization of the density from the saposin molecules. Six saposin molecules, each oriented at a 45° angle to the vertical axis, wrap around NfMCU stabilized in lipid. b, Ribbon diagram of NfMCU in complex with saposin. Approximately 79–81 residues of the 81-residue saposin molecule were modelled as a poly-alanine chain into the helix–turn–helix EM map density for saposin.
