Extended Data Fig. 9: Anti-α6 integrin-blocking antibody treatment prolongs survival, but does not alter disease burden in the bone marrow or spleen of Nalm-6-engrafted leukaemic mice.
From: Leukaemia hijacks a neural mechanism to invade the central nervous system
a, Schematic for the treatment of mice with the α6 integrin-neutralizing antibody. b, Kaplan–Meier survival curves for Nalm-6-engrafted mice treated with or without anti-integrin-α6 blocking antibodies. Two-sided log rank Mantel–Cox, n = 3 mice per treatment group, P = 0.0224. c, d, Disease burden at end point in the bone marrow and spleen of vehicle and anti-integrin-α6 antibody-treated Nalm-6-engrafted leukaemic mice. Data are mean ± s.e.m.; paired two-sided Student’s t-test, n = 3 mice per treatment group, P = 0.7874 (bone marrow), P = 0.1595 (spleen).
