Extended Data Fig. 6: Effect of copanilisib with or without ketogenic diet on growth of KPC tumour model K8082 grown in the flank of wild-type c57/bl6 mice.
From: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
a, Survival curves for mice with KPC K8082 allografts grown in the flank and treated as indicated with BAY 80-6946 alone or combined with pretreatment with a ketogenic diet as indicated (P value comparing BAY 80-6946 with the combination of BAY 80-6946 with ketogenic diet was 0.0019 by Mantel–Cox log-rank test). n = 5 mice per arm for vehicle, BAY 80-6946, and BAY 80-6946 + ketogenic diet; n = 4 for ketogenic diet alone. b, Volume of each tumour in this cohort plotted individually. c, d, Mean ± s.d. blood glucose (c) and c-peptide (d) in mice in b, c, 240 min after treatment. e, Mass of these mice over time on treatment. Tumours were allowed to grow until their diameters were >0.6 cm before the initiation of treatment.
