Extended Data Fig. 5: Effect of PI3K inhibitor treatments on PDX model of bladder cancer and syngeneic allograft models of PIK3CA mutant breast cancer.
From: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
a, Graph of tumour growth over time of a PDX from a patient with bladder cancer (Patient C) treated with the pan-PI3K inhibitor GDC-0941 or the β-sparing inhibitor GDC-0032, alone or with a ketogenic diet. Lines indicate mean tumour volume of each treatment group, points indicate individual tumour volumes over time. n = 5 tumours per arm. b, Mean ± s.d. tumour mass at the time of removal on day 12. c, d, Mean ± s.d. tumour growth over time (c) and tumour mass at time of removal (d) from mice with orthotopic allografts of a PIK3CA (H1047R) mutant mouse breast cancer, ES272, treated as indicated with BKM120 alone or in combination with a ketogenic diet. n = 4, 5, 5 tumours per arm for vehicle, BKM120 and BKM120 + ketogenic diet, respectively. e, Mean ± s.d. mass of mice over time.
