Extended Data Table 4 Gene expression changes in n = 2, 4 and 8 strains

From: Karyotype engineering by chromosome fusion leads to reproductive isolation in yeast

  1. a, Under- or overexpressed genes in n = 2, 4 and 8 strains. Genes in the fused chromosome arm are labelled as red. Genes in remaining unfused chromosome arms are in black. *Genes located near a telomere in n = 16 strain (within 20 kb). b, Comparison of the expression changes of 21 subtelomeric genes, with changes in Sir2Δ, Sir3Δ and Sir4Δ strains in ref. 40. Twenty-one subtelomeric genes that are significantly expressed in ref. 40 are listed in the first column. Whether they are significantly expressed in our strains (n = 2, n = 4 and n = 8) or not is listed in the second, third and fourth columns. The last row shows the correlation between fusion chromosome strains and Sir protein depletion strains. IMD1, YAR075W, YCL076W, YCL075W, YCL074W, YFL063W, YNL337W are removed by design. YCL068C, YCL065W and YCL064C are part of the silent HML locus. *Unfused telomeres. The P value was calculated by a one-sided Fisher’s exact test. c, Transcriptome change enrichments in sub-telomeres are significant in n = 2, 4 and 8 cells, calculated by one-sided Fisher’s exact test.
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