Extended Data Fig. 3: Comparison of the chromosomal interactions of SY6, SY13 and SY14 cells with those of BY4742 cells.

a, Z-score difference heatmaps. Bin length, 10 kb; red and blue show increased and decreased chromatin interactions, respectively. Green box highlights the interactions of the chromosome XV centromere with other chromosomes. b, Venn diagram of the number of significant (P < 0.01, q < 0.01) ‘inter’- and intra-chromosomal interactions (referring to their locations in the BY4742 genome). c, Strong chromosomal interactions of chromosome XV centromere regions in the BY4742, SY6, SY13 and SY14 genomes. The red bars indicate the centromeres and their flanking regions of 50 MboI restriction sites. Each arc throughout the chromosome XV centromere area represents one strong interaction. In SY6, SY13 and SY14, the reserved interactions are marked with black arcs and new interactions are marked with orange arcs. The green arrowheads mark the ten residual interactions near the centromere regions found in all four strains. d, 3D structures of chromosomes XV and II in SY6, SY13 and SY14 cells compared to those in BY4742 cells. The locations of the 10 residual interactions on Chr. XV and II are marked green.