Extended Data Fig. 3: 16p11.2 deletion decreases sociability, but not an anxiety-related behaviour.
From: 5-HT release in nucleus accumbens rescues social deficits in mouse autism model
a, b, Quantification of chamber time (a: control, F2,45 = 39.5, P < 0.001, n = 16; heterozygous, F2,21 = 23.39, P < 0.001, n = 8; homozygous, F2,21 = 31.54, P < 0.001, n = 8) and proximity time (b: control, F1,30 = 14.61, P < 0.001, n = 16; heterozygous, F1,14 = 10.14, P < 0.01, n = 8; homozygous, F1,14 = 11.88, P < 0.01, n = 8) in the three-chamber assay. c, Quantification of centre time (c: F10,135 = 1.03, P = 0.4215, n = 7–15) in control, heterozygous 16p11.2flx:Nes-creER and homozygous 16p11.2flx:Nes-creER mice. d, e, Quantification of chamber time in the three-chamber assay (d: 16p11.2flx:∆cre, F2,24 = 121.2, P < 0.001, n = 9; 16p11.2flx:cre, F2,24 = 27.86, P < 0.001, n = 9; Sert-cre:16p11.2flx, F2,21 = 84.95, P < 0.001, n = 8) and proximity time (e: 16p11.2flx:∆cre, F1,16 = 26.13, P < 0.001, n = 9; 16p11.2flx:cre, F1,16 = 6.885, P < 0.05, n = 9; Sert-cre:16p11.2flx, F1,14 = 44.00, P < 0.001, n = 8). f, Quantification of centre time in (c: F2,22 = 0.6019, P = 0.5565, n = 8–9) 16p11.2flx:∆cre, 16p11.2flx:cre and Sert-cre:16p11.2flx mice. Data are mean ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001; repeated measures, two-way ANOVA with Tukey’s multiple comparison post hoc test. Comparisons with no asterisk had P > 0.05 and were considered not significant.
