Extended Data Fig. 7: Homology model and conservation analysis for ten human FZDs.
From: Crystal structure of the Frizzled 4 receptor in a ligand-free state
a, Superposition of ten human FZD homology models. The green, thin regions represents high conservation, and the red, thick regions represent low conservation. b, Sequence alignment of pocket residues, with conserved amino acids across the FZD family highlighted in dark green. c, Conserved amino acids in the top of the FZD4 pocket. d, Conserved amino acids in the bottom of the FZD4 pocket.
