Extended Data Fig. 8: Molecular dynamics and mutation analysis of the Dishevelled-binding site.
From: Crystal structure of the Frizzled 4 receptor in a ligand-free state
a, The Dishevelled-binding site plotted as a moving average over a 10-ns window. Water molecules less than 10 Å from H348(N) were defined as proximal for this analysis. b, Total expression and cellular localization analysis for mutations in the Dishevelled-binding site (related to Fig. 4). The experiment was repeated using two independent methods with similar results.
