Extended Data Fig. 9: Analysis of the two unusual kinks.
From: Crystal structure of the Frizzled 4 receptor in a ligand-free state
a, Two kinks with conserved polar networks fluctuate between bent and straight conformations during simulation. b, Molecular dynamics traces of the kink 1 and kink 2 backbone distances plotted as a moving average over a 10-ns window. c, Total expression and cellular localization analysis of kink 1/kink 2 mutations (related to Fig. 4). The experiment was repeated using two independent methods with similar results.
