Extended Data Fig. 5: Phylogenetics of PanINs and matched primary tumours for patients PIN106 and PIN107.

See Supplementary Table 1 for sample identities. Gene names in orange text are SNVs or indels, in blue are copy-number losses, and in red are copy-number gains affecting putative driver genes. The sequencing data for each driver gene variant were manually reviewed to verify phylogenetic position. For each phylogeny, the numbers of acquired mutations are in black. The branch lengths are proportional to the number of SNVs or indels. The dashed lines indicate branches that have been extended to accommodate gene annotation and variant numbers. For each Bayesian heat map, samples are indicated on each row while variants are represented by each column. The colour of each tile indicates the probability that the variant is present or absent in the corresponding sample. Dark blue, >99.9% probability of being present; dark red, >99.9% probability of being absent. Light blue and red indicate lower probabilities; white tiles indicate approximately 50% probability. a, PIN106. The node leading from the first MRCA to the second MRCA has a confidence value of >99% and the node leading from the second MRCA to the third MRCA has a confidence value of 82%. b, PIN107.