Extended Data Fig. 4: Activation of PI3K–Akt–mTORC1–Runx2 axis by vesicular RANK.
From: Coupling of bone resorption and formation by RANKL reverse signalling
a, The effect of rapamycin on nuclear translocation of Runx2 in ST2 cells stimulated with mOC-SEVs. Histone deacetylase 2 (Hdac2) was used as reference nuclear protein. b, c, Influence of PI3K inhibitor (LY294002) (b) or mTORC1 inhibitor (rapamycin) (c) on activation of the PI3K–Akt–mTORC1 pathway in ST2 cells stimulated with mOC-SEVs.
