Extended Data Fig. 7: In vivo efficacy of ciprofloxacin.
From: Optimized arylomycins are a new class of Gram-negative antibiotics
Thigh infections initiated in neutropenic mice with the indicated Gram-negative bacterial species were treated with ciprofloxacin (Cipro) (n = 5 mice for E. coli and A. baumannii; n = 4 mice for K. pneumoniae and P. aeruginosa) or vehicle (n = 2 mice for P. aeruginosa, n = 4 mice for K. pneumoniae, n = 5 mice for E. coli and A. baumannii), and bacterial burden was quantified 20 h after infection. Ciprofloxacin was delivered subcutaneously once during the infection period, 2 h post-infection at the indicated dose. The pre-treatment and vehicle groups are identical to those shown in Fig. 4a, as these data were generated in the same studies. Broken red lines represent the limit of bacterial CFU determination, and the centre measure represents the mean with error bars representing s.e.m.
