Extended Data Fig. 1: Effects of pyramidotomy on tactile behaviour and gross locomotion in mice.
From: Touch and tactile neuropathic pain sensitivity are set by corticospinal projections
a, Correlation between CST ablation and tactile behaviours in mice with pyramidotomy. For individual animals that received pyramidotomy, tag number, image and quantification of L3 spinal cord sections stained with anti-PKCγ antibodies showing remaining CST axons, percentage of withdrawal response to low-threshold von Frey filament (0.16g) and light brush, and sense time to the tape are shown. b, c, Performance on ground walking (b, P = 0.14, hindlimb weight support; P = 0.81, hindlimb retraction; P = 0.41, hindlimb protraction; P = 0.81, inter-limb coordination; P = 0.20, fore–hindlimb coordination), and rotarod test (c, P = 0.87) in mice with sham surgery (n = 8) or pyramidotomy (n = 12). n.s., no statistical significance. Two-sided student’s t-test. Data shown as mean ± s.e.m.
