Extended Data Fig. 4: Mechanical allodynia induced by SNI or CFA injection is compromised in mice with pyramidotomy, but cold allodynia and mechanical hyperalgesia induced by SNI are not.
From: Touch and tactile neuropathic pain sensitivity are set by corticospinal projections
a, Schematic drawing of experimental paradigm. b–e, Measurement of punctate (b) and dynamic (c) mechanical allodynia, cold allodynia (d) and mechanical hyperalgesia (e) after SNI in mice that underwent sham surgery (n = 8) or pyramidotomy (n = 9) 1–21 days after SNI. b, P < 0.0001, P < 0.0001, P = 0.0012, P = 0.0004 and P = 0.041; c, P < 0.0001, P < 0.0001, P = 0.0004, P = 0.001 and P = 0.0045; d, P = 0.26, P = 0.33, P = 0.29, P > 0.99 and P > 0.99; e, P > 0.99, P = 0.15, P = 0.56, P > 0.99 and P = 0.74 for 1, 3, 7, 14 and 21 d post SNI, respectively. f, g, Measurement of punctate (f) and dynamic (g) mechanical allodynia in mice that underwent sham surgery (n = 6) or pyramidotomy (n = 6) 1–7 days after hindpaw CFA injection. f, P = 0.01, P = 0.01, P = 0.01, P < 0.0001 and P < 0.0001; g, P < 0.0001 for 1, 2, 3, 5 and 7d post CFA injection, respectively. Two-way repeated measures ANOVA followed by Bonferroni correction. Data shown as mean ± s.e.m.
