Extended Data Fig. 7: Mutant virus neutralization mapping and distribution of transmission pair characteristics among pairs with and without transferability of antibody response.
From: Tracing HIV-1 strains that imprint broadly neutralizing antibody responses
a, Changes in neutralization activity of wild-type and mutant viruses were compared for six bNAbs (four targeting the CD4 binding site, two targeting the V3 glycan) and for the plasma of the elite-neutralizing pair. Increases in mutant half-maximum inhibitory concentration (IC50) values >tenfold and decreases in mutant half-maximum neutralization titre (NT50) values >two fold appear coloured. b, c, Association of transmission pair characteristics and transferability of antibody response in n = 303 transmission pairs. Transferability of antibody responses was determined according to relatively liberal (strength threshold = 4 and similarity threshold = 0.4) and strict criteria (strength threshold = 5 and similarity threshold = 0.5). b, Influence of continuous variables (mean log10 HIV-1 RNA in the transmission pair, the difference of these log10 RNA values, and the genetic distance in the pair) tested by univariable logistic regression. c, Influence of categorical variables (acute infection, long virus evolution, infecting subtype, ethnicity and transmission mode) tested by two-tailed Fisher’s exact test. The area of a rectangle corresponds to the number of pairs with the respective characteristic. MSM, men who have sex with men; HET, heterosexual transmission; IDU, intravenous drug users.
