Extended Data Fig. 4: Similarity of neutralization and antibody-binding responses in subtype-B-infected transmission pairs.
From: Tracing HIV-1 strains that imprint broadly neutralizing antibody responses
a–d, To exclude influences of the subtype of the infecting virus, as a sensitivity analysis to Fig. 1a, b, the similarity of neutralization (a, b) and antibody-binding (c, d) responses was tested for the subset of subtype-B-infected transmission pairs (n = 254). a, c, Spearman correlation of the neutralization–antibody-binding response to each pseudovirus or antigen. Significant correlations (two-sided PSpearman < 0.05) are coloured. b, d, Average Spearman correlation of antibody responses in observed transmission pairs (n = 303) compared to two alternative scenarios: (1) completely random reassignment of recipients to transmitters and (2) random reassignment of recipients to transmitters with same demographics (subtype, ethnicity and untreated infection length). One-sided P values were derived from comparison with 1,000 reassignments. Each violin plot is smoothed using a normal kernel, and its width represents the likelihood of a certain average correlation in the respective alternative scenario. The medians are shown (white dots), each box spans the IQR and each whisker extends to the most extreme value no more than 1.5× IQR from the box.
