Extended Data Fig. 1: Hepatic cell proliferation in perfused liver periphery versus liver centre at E11.5.
From: Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival
a, b, c, Transversal section through a liver after injection of EdU into its lobes and WEC for 3 h. Magnified fields of view in the liver centre (a′, b′, c′) and the liver periphery (a′′, b′′, c′′), as indicated in c by white boxes. d, d′, e, e′, Transversal sections through E11.5 livers showing the liver centre (d, d′) and liver periphery (e, e′). f, Quantification of the Ki-67+ area in the liver centre versus liver periphery (n = 3 livers, *P = 0.0142 (119.40; 376.70)). Scale bars, 100 μm (a, b, c) and 50 μm (all other panels). Two-tailed paired Student’s t-test, 95% confidence interval (lower confidence limit; upper confidence limit).
