Extended Data Fig. 9: Phylogenetic trees of participants 9245, 9251, 9254 and 9255.
From: Combination therapy with anti-HIV-1 antibodies maintains viral suppression
Maximum likelihood phylogenetic trees of full-length env sequences of viruses isolated from Q2VOA cultures and rebound plasma SGA and rebound outgrowth from the two participants (9245 and 9251) with pre-existing resistance to one of the two antibodies and the two sensitive participants (9254 and 9255) who maintained viral suppression for >30 weeks (end of the study). Open and closed black rectangles indicate Q2VOA-derived viruses from week −2 and week 12, respectively. Rebound plasma SGA viruses are indicated by closed red rectangles. Asterisks indicate nodes with significant bootstrap values (bootstrap support ≥ 70%). Clones are denoted by coloured lines beside the phylogenetic tree. Numbers correspond to 3BNC117 and 10-1074 IC80 neutralization titres.
