Extended Data Fig. 10: Clonal distribution of the circulating latent reservoir and IUPM changes.
From: Combination therapy with anti-HIV-1 antibodies maintains viral suppression
a, Pie charts depicting the distribution of Q2VOA-derived env sequences obtained at weeks −2 (W−2) and week 12 (W12). Number in the inner circle indicates the total number of analysed env sequences. White represents sequences isolated only once across both time points and coloured slices represent identical sequences that appear more than once (clones). The size of each pie slice is proportional to the size of the clone. Red arrows denote clones that significantly change in size (P ≤ 0.05 (two-sided Fisher’s exact test)) between the two time points. b, Summary of clonal env sequences and IUPM in the nine individuals with an antibody-sensitive reservoir. c, IUPM versus time of viral rebound in the antibody-sensitive individuals (n = 7) who rebounded within the study observation period (30 weeks). P values were obtained using a two-tailed Pearson correlation test comparing the two variables.
