Extended Data Fig. 10: Class B GPCRs display similar active state conformations.
From: Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
a, b, Alignment of the CGRP–CLR–RAMP1, sCT–CTR, ExP5–GLP-1R and GLP-1–GLP-1R structures (aligned on the transmembrane domains). Regions of divergence between CLR/CTR and GLP-1R are circled. In a, RAMP1 has been omitted for clarity. c, Position of the Gαs-Ras domain in the CTR (left), GLP-1R (GLP-1 bound; middle) and GLP-1R (ExP5 bound; right). The receptor transmembrane domains were aligned. Only the CLR (blue) and RAMP1 (orange) are displayed for clarity. d, The Gαs-Ras domain from each of the four structures, aligned to the Gαs-Ras of the CGRP receptor (CGRPR) complex.
