Extended Data Fig. 3: Changes in cellular parameters elicited by lactate in carotid body glomus cells from wild-type and Olfr78−/− FRA mice. | Nature

Extended Data Fig. 3: Changes in cellular parameters elicited by lactate in carotid body glomus cells from wild-type and Olfr78−/− FRA mice.

From: The role of Olfr78 in the breathing circuit of mice

Extended Data Fig. 3

a, Immunohistochemical detection of GFP and tyrosine hydroxylase (TH) in a carotid body slice from an Olfr78−/− FRA mouse. b, Representative examples of quantal dopamine secretion from glomus cells in carotid body slices of wild-type FRA mice (left) and Olfr78−/− FRA mice (right) in response to external application of l-lactate (sodium lactate, 5 mM). c, Representative examples of increase in cytosolic Ca2+ levels elicited by l-lactate (5 mM) in single dissociated glomus cells from wild-type FRA mice (left) and Olfr78−/− FRA mice (right). d, Amplitude of changes in cytosolic Ca2+ levels induced by lactate in glomus cells from wild-type FRA mice (green, n = 16 cells, 5 mice) and Olfr78−/− FRA mice (purple, n = 14 cells, 5 mice) relative to the signal obtained with 40 mM K+. Data are mean ± s.e.m.

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