Extended Data Fig. 1: Ancestry principal components analysis of UK and Australian samples.
From: Common genetic variants contribute to risk of rare severe neurodevelopmental disorders
a, b, Reference samples (n = 2,504) from 1000 Genomes Phase 3, coloured by the five super-populations, used for a projection PCA of UK cohorts (DDD and UKHLS) (a) or Australian cohorts (b). c, d, All DDD cases (discovery n = 11,304 and from trios n = 930) (c) and all Australian cases (n = 2,283) (d) from their respective projection PCA with 1000 Genomes. Case samples from individuals with European ancestry are plotted in red and non-Europeans in grey. e, f, All UKHLS controls (n = 10,396) (e) and all Australian controls (n = 4,274) (f) from their respective projection PCA with 1000 Genomes. Control samples from individuals with European ancestry are plotted in blue and non-Europeans in grey. All cases and controls coloured in grey (in c–f) were excluded from analysis owing to non-European ancestry. UK cohorts are plotted after removal of samples that failed quality control, and Australian cohorts before removal of samples that failed quality control.
