Extended Data Fig. 2: Discovery GWAS of neurodevelopmental disorder risk.
From: Common genetic variants contribute to risk of rare severe neurodevelopmental disorders
a, Manhattan plot of discovery GWAS of neurodevelopmental disorder risk, with 6,987 DDD cases and 9,270 ancestry-matched UKHLS controls (both for individuals with European ancestry), using 4,134,438 variants, MAF ≥ 5%, chromosomes 1–22. P values were from a two-tailed χ2 distribution. Red line represents the threshold for genome-wide significance (P = 5 × 10−8). b, Quantile–quantile plot of discovery GWAS of neurodevelopmental disorder risk. Red line represents the expected values under the null hypothesis.
